DNA was obtained from peripheral blood white cells. Results: Significant difference was found in family history of alcoholism and use of other psychoactive substances to compare alcoholics with controls. When allelic frequencies for each category gender were considered, frequency of A2 allele carriers in ADH2 was found higher in male patients than controls. In women, the relative frequency for c1 allele in CYP2E1 was lower in controls than alcoholics. The ALDH2 locus is monomorphic.
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DNA was obtained from peripheral blood white cells. Results: Significant difference was found in family history of alcoholism and use of other psychoactive substances to compare alcoholics with controls. When allelic frequencies for each category gender were considered, frequency of A2 allele carriers in ADH2 was found higher in male patients than controls. In women, the relative frequency for c1 allele in CYP2E1 was lower in controls than alcoholics.
The ALDH2 locus is monomorphic. No significant differences in allele distributions of the loci examined to compare two populations were observed, however when stratifying the same trend was found that these differences tended to be significant.
Conclusions: This study allows us to conclude the positive association between family history of alcoholism and alcoholism suggesting that there is a favourable hereditary predisposition. Conflict of interest: Manifest not present conflicts of interest.
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Vidal F, et al. J Hepatol. PMID: Nakamura K, et al. Arukoru Kenkyuto Yakubutsu Ison. PMID: Japanese. Konishi T, et al. Exp Mol Pathol. Harada S. Nihon Arukoru Yakubutsu Igakkai Zasshi. PMID: Review.
Chrostek L, Szmitkowski M. Chrostek L, et al. Postepy Hig Med Dosw. Show more similar articles See all similar articles. Mansoori AA, et al. Asian Pac J Cancer Prev. References WHO. Global status report on alcohol and health. Library Cataloguing-in-Publication Data; Italia: Influence of genetic variations of ethanol-metabolizing enzymes on phenotypes of alcohol-related disorders. Ann N Y Acad Sci. Alcohol Clin Exp Res. The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants.
Alcohol Res Health. Publication types Research Support, Non-U. Gov't Actions. MeSH terms Adult Actions. Aldehyde Dehydrogenase, Mitochondrial Actions. Case-Control Studies Actions. Colombia Actions. Family Actions. Female Actions. Gene Frequency Actions. Genetic Predisposition to Disease Actions. Genotype Actions. Humans Actions.
Male Actions. ADH1C protein, human Actions. Alcohol Dehydrogenase Actions. ALDH2 protein, human Actions. Aldehyde Dehydrogenase Actions.
Interacción de gen no alélico
Genetic epidemiology research designs. This article describes the features of the epidemiologic research designs most commonly used in genetic association studies. Case-control studies are efficient in evaluating associations between candidate genes and disease. Cohort studies, in contrast, yield a greater degree of causality but are not efficient for the initial exploration to identify gene-disease associations. Cross-sectional studies are less expensive, require less time, and are useful for estimating the prevalence of diseases, risk factors, and genetic variants. Family-based studies have been successful in finding alleles that confer greater risk for developing Mendelian inheritance disorders. Keywords: genetic research; epidemiologic research design; genetic association studies; relative risk public health.
Por otra parte, cuando dos mutaciones en conjunto conducen a un fenotipo menos pato de lo esperado por los efectos individuales, se llama epistasis negativa. Para un sistema con dos locus y con dos alelos hay ocho tipos independientes de interacciones de genes. Algunos grupos de mutaciones especialmente aditivas dentro han sido descubiertas dentro de algunos genes. La epistasis entre los genomas de organismos ocurre debido a las interacciones entre los genes dentro del genoma.